Seconded on the 1974 Washington Nat’l League and the 1981 fleers. These should be very high up the list as they are largely responsible for a trend in people looking for errors.
I would also say the 1952 Page/Sain cards belong. T206 Magie and Doyle. Some of the 89 Upper Decks.
I don’t think there are 50 that have had a significant impact on the hobby as a whole. There’s a handful that have, and everything else is restricted to the niche of master set collectors really caring about and there relative popularity within that niche.
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