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barrysloateIf you make a profit on the sale of anything, you are liable to pay taxes. If it is your hobby and not your main source of income, I believe it is taxed differently. I would be careful about taking a tax write-off on a loss however, as it could raise a red flag.
If you sell one baseball card during the year and make a $50 profit, nobody will know about it. If you sell your collection or a major portion of it and accept a large check, I would speak to your accountant about it.