I think it could happen. The '68 Ryan/Koosman and the '89 UD Griffey are already very popular, but not as much as the Mantle. Mickey Mantle defined the 1950s and 60s for baseball, and until someone else does that, there will not be another '52 Mantle. Also, I think that even with manufactured scarcity there can still be huge demand for some cards, take the 2008 Topps Kershaw for example.
Just my thoughts
Owen
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1955 Topps 171/206 
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