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T207-most expensive, Irving Lewis (no distinction made for arm patch), last to acquire, Donnelly.

T200-most expensive, Detroit, last to acquire, Boston NL. I agree with Anthony on this one.

D304-most expensive, Cobb, last to acquire, Tenney.

George C. Miller-most expensive, Gehrig, last to acquire, Melillo.

N566 Newsboys-most expensive and last to acquire, Ward, arms folded.

D322 most expensive, Wagner, last to acquire, Dreyfuss, before he was a HOFer.

T209 color, for me Lane was the easiest. I had two for a while. Pope was the toughest for me.

E103 -most expensive, Cobb, last to acquire, Crawford.

N300-most expensive, Anson, last to acquire, Kinslow (no team).

N43 -most expensive, Ewing, last to acquire, Miller took years although I have no reason to believe he is more rare than the others.

No wonder I feel old!

Edited to add that I went with a cancelled Andrews for my R300 set, otherwise that would have been the toughest (near impossible) card in that set. Like the 33 Goudey set with Lajoie, there is no question which are the toughest cards in these sets, and what the reason is. Others are much nore nebulous.