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W.M.Hands down favorite card for me is a e90-1 Shoeless Joe. If I ever get one I will never buy another card.
I have a few favorites in my personal collection:
1952 Topps Mantle
1933 Goudey #188 Ruth (My wife bought it for me that's the reason I married her).
1933 Goudey Gehrig
1909 t206 Cobb red background
1909 t206 Walter Johnson portrait