My take has always been corners, and I am a corner junkie. Having the cards I purchased as a kid (in the late 60's and early 70's), my personal preference is for the cards to be as close to the condition they were in when they came out of the pack.
Straight from the factory issues such as centering and registration have always been secondary or tertiary to me, versus willful (or unwillfull - sp? ) damage.
However, I will admit I now do look at centering and (to a lesser degree) registration when making a decent dollar purchase. I have this forum to thank for bringing these factors into my current buying habits.
