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JimBAs others mentioned, the standard is to consider the qualifier as a two-grade drop. However, it really depends on how much the fault affects the overall quality and eye-appeal of the card. If it has a disastrous affect, it might hurt more. If it is not really a big deal, but a technical fault, the affect might be less. Also, one has to consider the card and the set. If the card is extremely rare, it may not have much affect at all since buyers will want to get it in any condition they can. If it is from a set that is not too tough, the affect could be greater.
My point is that there is no simple, one-size-fits-all answer. Hope this helps.
JimB