Well, for this age of sets:
Topps 1952, 1954, 1956, 1972, and 1975 are always popular.
High numbered cards from many sets are popular.
When you say you're looking to invest, are you talking about high grade hall of famers? Normally the biggest gains are made in Hall of Fame rookie cards in high grade. Commons normally tread water, unless they're in high grade and being chased by registry set collectors, or are high-numbered or Short Prints.
Oddballs are sometimes fun: Post, Jello, DanDee, Hires, Berk Ross can be worthwhile if you learn all the little variations.
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PWCC: The Fish Stinks From the Head
PSA: Regularly Get Cheated
BGS: Can't detect trimming on modern
SGC: Closed auto authentication business
JSA: Approved same T206 Autos before SGC
Oh, what a difference a year makes.
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