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hankronIn general, most reprints in an online auction-- whether it's of a T206 or a 1955 Bowman-- simply don't look right to someone who closely follows cards, both collecting and watching online auctions. For example, irrelevant to the issues of the color of the borders versus the color in the image, most 1915 Cracker Jack reprint simply don't look genuine. Most T206 and Allen & Ginter reprints simply don't look good.
By the actively collecting and avidly following online auctions of real material, collectors will gain an eye that will help them to detect fakes.
As Gary suggested, you should also look at the seller and the quality of the description. There are many, many collectors who see no difference between buying a raw Cap Anson Old Judge from Lew Lipset and buying it from a seller who specializes in beanie babies. No joke.