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davidcyclebackIf the autograph is sharp, it's probably worth more with the signature. If you get the card and sig authenticated by PSA or SGC, you'll have no trouble finding a buyer.
For getting autographs signed, consider the value of he card and the value of a signature. It's not always best to get a $3 autograph on a $1,000 card, though it would be fine to get the $3 autograph on a $3 or even $20 card. For example, if you have a Gem Mint 1968 Topps Nolan Ryan/Jerry Koosman rookie, it might not be the best idea to have Koosman sign across the front. But getting Koosman's sig on a 1978 Topps sound like a good idea. With the 53T Mantle, the card is valuable and Mantle's autograph, while not rare, is also valueable.
For lower grade semi-valuable cards, an autograph can be a nice edition and raise value. For example, an Eddie Murray or Robin Yount signed Very Good rookie.