It Depends
Being tied almost exclusively to the Old Judge issue these days, centering means almost nothing to me. If I can find a card that is on my want list and has a nice picture, I am not going to be concerned about centering at all.
Even when I was collecting other pre-war and post-war issues, poor centering did not detract from the aesthetics of the card for me as much as bad edges, bad corners and a bad image did.
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