I collect some.  For modern era I prefer the mfg certified and issued cards.  I mean, where else can you get a genuine sig of a HOFer for $10-$20?  Great value for the collector IMO.  
I also collect sigs I get in person.  
I have a few vintage sigs of people who've done something I admire, like several of the 506th PIR (Band of Brothers) soldiers from WWII.  
And I have several sigs of my cousin in various formats:
1951 Topps Ringside card, contract and TLS referencing autographing Topps Ringside cards:
 
 
 
Poster, secretarially signed:
 
Autographed photo:
