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MWThe E121 "Series of 80" is from 1921. 121 different cards (not including variations) comprise this series.
The E121 "Series of 120" is from 1922. It has the same general appearance as the 1921 set except for some variations in the printing on the bottom. 126 different cards (not including variations) comprise this series. The reverse is different from the 1921 set since it contains the words "This set consists of pictures of 120 of the leading Base Ball Stars" instead of only "eighty of the leading Base Ball Stars."
There is also an E122 "Series of 80" Set from 1922. It is more difficult to find than either of the E121 sets and it has a somewhat different appearance/design on front. The reverse side is the same as the E121 "Series of 80" made a year earlier. 81 different cards (not including variations) comprise this series.