Toughest Topps wax packs to get are 56 and 58. Only have penny pack for both. Anthony ( Griffins) has both I think. A Salesman sample for this year is also tough
Checklists are tough. Getting all the white and gray backs for 1-180 is expensive since so many star cards are involved
The different versions of the team cards are challenging but fun
George Vrecheck has done an SCD article on the wo cropping versions that exist for many of the cards.
If you are OCD there are also many colored line variants ( print offsets) for many of the cards, including Williams, between the name and team/position boxes.
Also the 56 ( along with the 55 ) Hocus Focus baseball subset is in my experience the hardest Topps issued at wide retail set to complete
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