Mostly agree with earlier response
If I am interested and it has a BIN that I believe to be out of line, I make my offer and back it up with facts (recently sold comps for example). If I can't back it up with something, then I usually don't bother sending. Some guys don't care, others are willing to negotiate. In terms of offer amount - usually if it's that far out of line, I'll throw my best offer out off the bat and be willing to walk if it's not good enough. On something that's closer I will go below my best offer to leave room for the negotiation.
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