I'm a little surprised that people doubt the card would be desirable. It may not sell at the price it listed for but there is a dedicated community of error and scrap collectors, especially of Topps cards, and the fuglier the card and the greater the rep of the player or issue, the more desirable it is. The most extreme errors carry the highest values:
Blackless 1971 Topps:
Flipped stock 1972 Topps:
Terrible misprints and miscuts:
Printers' scrap is also desirable: Topps printing process items that should never have gotten out of the factory are unique and interesting to collectors of the player or issue. 1971 Topps hockey is one of my favorites and the Hull is my favorite card of his, so I happily acquired this scrap (not from Carmine):
Printing process material issued by the Topps Vault also sell well.
The Mantle looks like printers' scrap used to clear the press between runs that was rescued from the trash and hand cut. My guess is that the sheet had some sort of flaw that was caught in the printing process. To me, the card looks like it is missing the shellac coating on the front. Altered is the wrong designation but the truth still is a strong combo for the collectors who are into that sort of stuff.
As for wrong back wrong/front combos caused by the sheet being fed into the printer at a 180 degree orientation from normal there are collectors. Whether it is a HOF card or not depends on whether you are buying or selling and how clear it is. I have this one:
When I sell it you better believe it is going to be marketed as a 1941 Play Ball Joe DiMaggio error card.
The 'Mantle' and 'Robinson' are great examples of 1952 Topps scraps but may be priced a bit too aggressively for the misprint community given how hard it is to see the superstar elements.